Muby chemicals, is the flagship company in Mubychem Group, established in 1976, It has several manufacturing units in its wings, making Inorganic Chemicals Pharmaceutical Excipients, Fragrances & Flavour Chemicals in India. Mubychem Group has manufacturing facilities spread across Western India and sales purchase agents in several countries. The associated manufacturing units are accredited with certifications like FDA) GMP Approval, ISO-9001:2008 & ISO-22000:2005 Certification, "REACH" Pre-registration, Kosher, Halal & HACCP Certification.
Methylene Blue USP Methylthioninium Chloride BP Methylene Blue ManufacturersSpecifications of Methylene Blue are as follows:
Chemical Formula: C16H18N3CIS
Molecular Weight: 319.85 gm / mole
Chemical Name: 3,7-bis(Dimethylamino)-phenazathionium chloride Tetramethylthionine chloride
CAS Registration: 61-73-4
C.I No.: 52015
Appearance: Dark Green Crystalline Powder
Assay (as is basis): 80 % - 85%
Assay (on dry basis): 98% -101%
Loss on drying: 10% -20%
Solubility: Clear Blue Solution
Ash content: 1% Max
Residual Solvent: Nil
Aluminium: 100 ppm Max
Cadmium: 1ppm Max
Chromium: 10ppm Max
Copper: 50ppm Max
Tin: 10 ppm Max
Iron: 100ppm Max
Manganese: 10ppm Max
Molybdenum: 10ppm Max
Methylene Blue USP
Methylene BlueMethylene Blue contains not less than 98.0 percent and not more than 103.0 percent of C16H18ClN3S, calculated on the dried basis.
Phenothiazin-5-ium, 3,7-bis(dimethylamino)-, chloride, trihydrate.
C.I. Basic Blue 9 trihydrate [7220-79-3]
Anhydrous 319.86 [61-73-4]
Identification: Infrared Absorption 197K .
Loss on drying— Dry it at 75 and at a pressure not exceeding 5 mm of mercury for 4 hours: it loses between 8.0% and 18.0% of its weight.50C(AU / AS)
Residue on ignition: not more than 1.2%.
Arsenic— Prepare the Test Preparation by mixing 0.375 g with 10 mL of water in the arsine generator flask. Add 15 mL of nitric acid and 5 mL of perchloric acid, mix, and heat cautiously to the production of strong fumes of perchloric acid. Cool, wash down the sides of the flask with water, and again heat to strong fumes. Again cool, wash down the sides of the flask, and heat to fumes. Cool, dilute with water to 52 mL, and add 3 mL of hydrochloric acid: the resulting solution meets the requirements of the test, the addition of 20 mL of 7 N sulfuric acid specified for Procedure being omitted. The limit is 8 ppm.
Copper or zinc— Ignite 1.0 g in a porcelain crucible, using as low a temperature as practicable, until all of the carbon is oxidized. Cool the residue, add 15 mL of 2 N nitric acid, and boil for 5 minutes. Filter the cooled solution, and wash any residue with 10 mL of water. To the combined filtrate and washing add an excess of 6 N ammonium hydroxide, and filter the solution into a 50 mL volumetric flask. Wash the precipitate with small portions of water, adding the washings to the filtrate, dilute the solution with water to volume, and mix. To 25 mL of the solution add 10 mL of hydrogen sulfide TS: no turbidity is produced within 5 minutes (absence of zinc). Any dark color produced does not exceed that of a control prepared by boiling a quantity of cupric sulfate, equivalent to 200 @g of copper, with 15 mL of 2 N nitric acid for 5 minutes and by treating this solution as directed above, beginning with “Filter the cooled solution” (0.02% of copper).
Chromatographic purity— Quantitatively dissolve an accurately weighed quantity of Methylene Blue in methanol to obtain a Test solution containing 1.0 mg per mL Dissolve a suitable quantity of USP Methylene Blue RS in methanol to obtain a Standard solution having a concentration of 100 @g per mL. Quantitatively dilute a portion of this solution with methanol to obtain a Diluted standard solution having a concentration of 10 @g per mL. Apply 5 @L each of the Test solution, the Standard solution, and the Diluted standard solution to a suitable thin-layer chromatographic plate coated with a 0.25-mm layer of octadecylsilanized chromatographic silica gel. Allow the spots to dry, and develop the chromatogram in a chromatographic chamber with a solvent system consisting of a mixture of the upper layer separated from a well-shaken mixture of water, n-butanol, and glacial acetic acid (100:80:20), until the solvent front has moved about three-fourths of the length of the plate. Remove the plate from the chamber, allow the solvent to evaporate, and visually locate the spots on the plate: the RF value of the principal spot in the chromatogram from the Test solution corresponds to that from the Standard solution, and other spots, if present in the chromatogram from the Test solution, consist of a secondary spot that does not exceed in size or intensity, the principal spot obtained from the Standard solution (10%), and not more than two additional spots, neither of which exceeds in size or intensity the principal spot from the Diluted standard solution (1%)Assay— Transfer about 100 mg of Methylene Blue, accurately weighed, to a 250-mL volumetric flask, dissolve in and dilute with diluted alcohol to volume, and mix. Transfer 5.0 mL of this solution to a 100-mL volumetric flask, dilute with diluted alcohol to volume, and mix. Transfer 5.0 mL of this solution to a 50-mL volumetric flask, dilute with diluted alcohol to volume, and mix. This solution contains about 2 @g per mL. Dissolve an accurately weighed quantity of USP Methylene Blue RS in diluted alcohol, and dilute quantitatively and stepwise with diluted alcohol to obtain a Standard solution having a known concentration of about 2 @g per mL. Concomitantly determine the absorbance of both solutions in 1-cm cells at the wavelength of maximum absorbance at about 663 nm, with a suitable spectrophotometer, using diluted alcohol as the blank. Calculate the quantity, in mg, of C16H18ClN3S in the Methylene Blue taken by the formula:
in which C is the concentration, in @g per mL, of anhydrous methylene blue in the Standard solution; and AU and AS are the absorbance of the solution of Methylene Blue and the Standard solution, respectively.
Methylthioninium Chloride BP or Methylthioninium Chloride Ph. Eur is also offered.
IUPAC name is 3,7-Bis(dimethylamino)phenothiazin-5-ylium chloride or 3,7-bis(Dimethylamino)-phenothiazin-5-ium chloride
Methylene Blue USP Methylthioninium Chloride BP Manufacturers:
Muby Chemicals & Associated Cos
S-8, SARIFA MANSION, 2ND FLANK ROAD, CHINCHBUNDER, MUMBAI 400009, INDIA.
TEL: (Off.) 91-22-23770100, 23726950. 91-22-23728264. Gujarat & Mumbai India.
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Last updated 21-nov-17
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Muby.in Pharmaceutical IP BP USP Grades of Chemicals Ammonium Chloride Benzyl Alcohol BP Benzyl Alcohol USP, ACS Boric Acid USP-NF, BP Borax BP, USP-NF, ACS Boric Acid IP, ACS Calcium Chloride Calcium Hydroxide BP, USP Calcium Hydroxide FCC, ACS Calcium Oxide FCC, USP Calcium Saccharate Calcium Sulfate USP, BP Calcium Sulfate FCC, ACS Chromic Chloride USP, Chromium Chloride Gentian Violet USP, Crystal violet BP Magnesium Chloride BP, IP Magnesium Chloride USP-NF, FCC, ACS Magnesium Sulphate BP, IP Magnesium Sulfate USP, FCC ACS Manganese Chloride FCC, ACS Manganese Sulphate BP, Manganese Sulfate USP Manganese Sulfate ACS, FCC Magnesium Chloride Methyl-thioninium Chloride BP, Methylene Blue USP Maleic acid Potassium bromide Potassium Chloride Potassium nitrate Potassium nitrite Potassium Phosphate Sodium Acetate Sodium Bicarbonate BP, IP Sodium Bicarbonate USP, FCC, ACS Sodium Diacetate Sodium Phosphate Sodium propionate Sodium Thiosulphate Sodium Thiosulfate BP-USP-IP Sodium Thiosulfate-ACS-FCC-Food Sodium Hydroxide Pellets USP-NF FCC ACS Caustic Soda Pellets BP IP Sodium nitrite Sodium nitrate Zinc Chloride Other Chemical Products Ammonium Phosphate Ammonium persulfate Barium chloride Calcium propionate Ceric ammonium nitrate Cupric Chloride Calcium Nitrite Nitrate Isatoic Anhydride HEDP Hhydroxyethylidene diphosphonic acid Potassium Iodide Sodium Bromide Sodium Formaldehyde Bisulfite
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